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    Experimental rodent models of prostatitis: limitations and potential

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    Testosterone inhibits the growth of prostate cancer xenografts in nude mice

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    Testosterone inhibits the growth of prostate cancer xenografts in nude mice

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    Background: Traditional beliefs of androgen's stimulating effects on the growth of prostate cancer PCa have been challenged in recent years. Our previous in vitro study indicated that physiological normal levels of androgens inhibited the proliferation of PCa cells. In this in vivo study, the ability of testosterone T to inhibit PCa growth was assessed by testing the tumor incidence rate and tumor growth rate of PCa xenografts on nude mice. PCa cells were injected subcutaneously to nude mice and tumor incidence rate and tumor growth rate of PCa xenografts were tested.
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